Journal
CHEMCATCHEM
Volume 9, Issue 24, Pages 4475-4479Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cctc.201701379
Keywords
amination; amines; asymmetric synthesis; biocatalysis; enzymes
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Funding
- European Union's Seventh Framework Programme (FP7) [115360]
- EFPIA companies
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Chiral secondary and tertiary amines are ubiquitous in pharmaceutical, fine, and specialty chemicals, but their synthesis typically suffers from significant sustainability and selectivity challenges. Biocatalytic alternatives, such as enzyme-catalyzed reductive amination, offer several advantages over traditional chemistry, but industrial applicability has not yet been demonstrated. Herein, we report the use of cell lysates expressing imine reductases operating at 1:1 stoichiometry for a variety of amines and carbonyls. A collection of biocatalysts with diversity in coverage of small molecules and direct industrial applicability is presented.
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