Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 99, Pages 13245-13248Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc07288k
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Funding
- National Natural Science Foundation of China [51772002, 51472002, 31771310, 51432001]
- Science and Technology Plan of Anhui Province [1604b0602016]
- Ministry of Education of the People's Republic of China
- Higher Education Revitalization Plan Talent Project of Anhui Province
- Anhui University [201610357007]
- Anhui University
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The conveniently obtained water-soluble small-molecule L1-5 were selective for RNA with remarkable off-on'' two-photon fluorescence responses in vitro and in vivo, showing that L1-5 can surprisingly stain mitochondria or nucleoli individually with orange fluorescence under different focal lengths. Compounds L6-8 were prepared, for comparison, to further explore the mechanism of the binding of L1-5 with RNA, which revealed that the synergistic effect of the amino group and the pyridinium cation played a significant role in distinct cell imaging.
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