Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 40, Issue -, Pages 58-64Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2017.10.020
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Funding
- MRC Career Development Award [MR/L00903X/1]
- NIH from NIAID [1R01DE022069-01A1]
- NIH from NIDCR [1 R01 AI116025-01]
- Medical Research Council [MR/L00903X/1] Funding Source: researchfish
- MRC [MR/L00903X/1] Funding Source: UKRI
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Fungi are ubiquitous transient or persistent human colonisers, and form the mycobiome with shifts in niche specific mycobiomes (dysbiosis) being associated with various diseases. These complex interactions of fungal species with the human host can be viewed as a spectrum of symbiotic relationships (i.e. commensal, parasitic, mutualistic, amensalistic). The host relevant outcome of the relationship is the damage to benefit ratio, elegantly described in the damage response framework. This review focuses on Candida albicans, which is the most well studied human fungal symbiont clinically and experimentally, its transition from commensalism to parasitism within the human host, and the factors that influence this relationship.
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