Journal
TETRAHEDRON LETTERS
Volume 58, Issue 43, Pages 4043-4047Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2017.09.001
Keywords
Tandem reaction; One-pot synthesis; Cross-coupling reaction; Hydroamination; Copper catalyst
Categories
Funding
- JSPS KAKENHI [16K14049, 26860168]
- Society of Iodine Science
- Grants-in-Aid for Scientific Research [26860168, 16H04138, 16K14049] Funding Source: KAKEN
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A copper-catalyzed tandem reaction with vinyl halides and 2-aminobenzamides has been developed. In this synthetic route, cross-coupling reaction of the amide moiety with vinyl halides initially progresses, followed by hydroamination, to provide 2,2-disubstituted quinazolinone derivatives. Moreover, the tandem reaction is used in a one-pot synthesis beginning with alkyne hydroiodination by PPh3, I-2, and H2O. (C) 2017 Elsevier Ltd. All rights reserved.
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