Journal
TETRAHEDRON LETTERS
Volume 58, Issue 40, Pages 3897-3900Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2017.08.073
Keywords
Taxus wallichiana; Taxaceae; Opened-oxetane ring; C-20 benzoyloxy; alpha-Glucosidase
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Funding
- Vietnam National University Ho Chi Minh City [A2015-18-02]
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Two new taxanes, named wallitaxane G (1) and H (2), were isolated from the roots of Taxus wallichiana (Taxaceae), together with nine known compounds (3-11). Their structures were elucidated on the basis of NMR spectroscopic analysis and the relative configurations of 1 and 2 were determined based on NOESY data. Wallitaxane H (2) showed the most potent cc-glucosidase inhibitory activity, with an IC50 value of 16.1 M. Plausible biosynthetic pathways for the formation of 1 and 2 were proposed based on oxetane ring-opening and benzoyl migration. (C) 2017 Elsevier Ltd. All rights reserved.
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