Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 40, Issue -, Pages 168-174Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2017.11.029
Keywords
-
Categories
Funding
- Intramural Research Program of the Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), NIH [Z01AI000947]
Ask authors/readers for more resources
Malaria is caused by infection with Plasmodium parasites that have a complex life cycle. The parasite protein P47 is critical for disease transmission. P47 mediates mosquito immune evasion in both Plasmodium berghei (Pbs47) and Plasmodium falciparum (Pfs47), and has been shown to be important for optimal female gamete fertility in P. berghei. Pfs47 presents strong geographic structure in natural P. falciparum populations, consistent with natural selection of Pfs47 haplotypes by the mosquito immune system as the parasite adapted to new vector species worldwide. These key functions make Plasmodium P47 an attractive target to disrupt malaria transmission.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available