Journal
TETRAHEDRON LETTERS
Volume 58, Issue 24, Pages 2360-2365Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2017.05.006
Keywords
Ionic liquid; Knoevenagel condensation; Aqueous synthesis; Room temperature; Recyclable catalyst; Gram scale
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Funding
- National Natural Science Foundation of China [21502042, 51403051, 21477033, 21204018]
- Scientific Research Key Project Fund of Henan Provincial Education Department [15A150041, 16A150003]
- Scientific Research Fund of Henan University [2013YBZR008]
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A series of novel N-methyl morpholine (Nmm) based ionic liquids with 1,2-propanediol group were synthesized and used as catalysts for Knoevenagel condensation at room temperature in water. Under the effect of the catalyst, various aldehydes or aliphatic ketones could react with a wide range of activated methylene compounds well, including malononitrile, alkyl cyanoacetate, cyanoacetamide, beta-diketone, barbituric acid, 2-arylacetonitrile and thiazolidinedione. Furthermore, most of the products could be separated just by filtrating and washing with water. Additionally, the catalyst is recyclable and applicable for the large-scale synthesis. (C) 2017 Elsevier Ltd. All rights reserved.
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