Journal
TETRAHEDRON LETTERS
Volume 58, Issue 15, Pages 1501-1506Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2017.03.003
Keywords
Cross coupling; Dehydrative; Iron catalyst; Quinazoline
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Funding
- Council of Scientific and Industrial Research (CSIR-India)
- University Grants Commission (UGC-India) for the award of Research Fellowships
- CSIR [CSC-0123]
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An operationally simple, efficient and straight forward approach was developed for the synthesis of new hybrid nitrogen heterocycles bearing dihydroquinazoline with quinoline, isoquinoline, quinoxaline and azole via iron-catalyzed dehydrative cross coupling reaction between heterocyclic aminol and 2-methyl azaarenes. Furthermore, this protocol applied to couple simple methyl ketones to achieve C4-alkylated-dihydroquinazolines with broad substrate scope. (C) 2017 Elsevier Ltd. All rights reserved.
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