Journal
TETRAHEDRON LETTERS
Volume 58, Issue 7, Pages 614-617Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2016.12.086
Keywords
Palladium; C-H activation; 1,4-Disubstituted-1,2,3-triazoles; Acetoxylation; Regioselectivity
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Funding
- National Natural Science Foundation of China [21662020, 51363012]
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A facile and efficient method for the regioselective acetoxylation of 1,4-disubstituted 1,2,3-triazoles via Pd-catalyzed C-H bond activation was developed. The cheap acetic acid was applied as the acetoxyl source to convert aromatic sp(2) C-H bonds into C-O bonds in high regioselectivity, employing 1,2,3-triazole as an elegant directing group and K2S2O8 as the oxidant. A range of 1,2,3-triazoles bearing acetoxyl group can be synthesized with the reaction facilely. (C) 2017 Elsevier Ltd. All rights reserved.
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