Palladium-catalyzed acetoxylation of arenes by 1,2,3-triazole-directed C-H activation

A facile and efficient method for the regioselective acetoxylation of 1,4-disubstituted 1,2,3-triazoles via Pd-catalyzed C-H bond activation was developed. The cheap acetic acid was applied as the acetoxyl source to convert aromatic sp(2) C-H bonds into C-O bonds in high regioselectivity, employing 1,2,3-triazole as an elegant directing group and K2S2O8 as the oxidant. A range of 1,2,3-triazoles bearing acetoxyl group can be synthesized with the reaction facilely. (C) 2017 Elsevier Ltd. All rights reserved.