Journal
TETRAHEDRON LETTERS
Volume 58, Issue 46, Pages 4400-4402Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2017.10.024
Keywords
Iridium; Alkylation; Catalysis; Microwave; Amino naphthoquinone
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Funding
- Leeds University
- Engineering and Physical Sciences Research Council [EP/K039202/1] Funding Source: researchfish
- EPSRC [EP/K039202/1] Funding Source: UKRI
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2'-Hydroxyacetophenone was alkylated with a range of substituted benzyl and heteroaryl alcohols to afford the corresponding C-alkylated products in good yields under microwave irradiation. The C-alkylated products were reacted with bromoacetonitrile to afford 2-amino-3-benzyl 1,4-naphthoquinone derivatives in moderate yields. (C) 2017 Elsevier Ltd. All rights reserved.
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