Journal
TETRAHEDRON LETTERS
Volume 58, Issue 43, Pages 4111-4114Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2017.09.042
Keywords
Pyrazole; Halogenation; Oxone; Green chemistry
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Funding
- Elizabethtown College
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A mild, inexpensive, and operationally simple pyrazole halogenation method utilizing Oxone and sodium halide salts is reported. This work documents 17 examples of alkyl, aryl, allyl, and benzyl substituted 4-chloro and 4-bromopyrazoles, obtained in up to 93% yield. Reactions are performed in water under ambient conditions and generation of organic byproducts is avoided. (C) 2017 Elsevier Ltd. All rights reserved.
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