4.4 Article

SF3•Et2O catalyzed intramolecular cyclization of diethyl 2-(dialkoxyphosphorylethyny1)-2-arylaminomalonates to 3-phosphonylated indoles

Journal

TETRAHEDRON LETTERS
Volume 58, Issue 30, Pages 2997-3001

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2017.06.062

Keywords

Phosphorylated indoles; Phosphonylated indoles; Aminomalonates; Phosphonylated 2-arylaminomalonic esters; Decarboxylation

Funding

  1. Russian Foundation for Basic Research [16-03-00474]

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The boron trifluoride diethyl etherate catalyzed intramolecular cyclization of diethyl 2-(dialkoxyphosphorylethynyl)-2-arylaminomalonates afforded a series of novel 3-phosphonylated indoles, diethyl 2[3-(dialkoxyphosphoryl)-1H-indol-2-yl]propanedioates. Decarboxylation of the latter compounds resulted in the formation of ethyl 2-13-(dialkoxyphosphory1)-1H-indo1-2-yljacetates. (C) 2017 Elsevier Ltd. All rights reserved.

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