Journal
ANNALS OF INDIAN ACADEMY OF NEUROLOGY
Volume 20, Issue 3, Pages 274-277Publisher
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
DOI: 10.4103/aian.AIAN_102_17
Keywords
Autonomic dysfunction; chronic inflammatory demyelinating polyneuropathy; orthostatic hypotension; postural orthostatic tachycardia syndrome; valsalva maneuver
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Introduction: In chronic inflammatory demyelinating polyneuropathy (CIDP), emphasis has been on motor disabilities, and autonomic dysfunction in these patients has not been addressed systematically. Materials and Methods: Autonomic function was prospectively analyzed in 38 patients with CIDP. Quantitative autonomic function testing was done using Finometer (R) PRO and severity of adrenergic and cardiovagal dysfunction graded according to composite autonomic severity score and sudomotor dysfunction assessed using sympathetic skin response. Results: Thirty-four (89%) patients had features of autonomic dysfunction. Thirty-three (86%) patients had cardiovagal dysfunction, 21 (55%) had adrenergic dysfunction, and 24 (63%) had sudomotor dysfunction. Autonomic dysfunction was mild to moderate in the majority (86%). Conclusions: Autonomic dysfunction in CIDP is underreported and potentially amenable to therapy. Our cohort had a high proportion of adrenergic dysfunction compared to previous studies.
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