Journal
TETRAHEDRON LETTERS
Volume 58, Issue 35, Pages 3426-3428Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2017.07.062
Keywords
Vildagliptin; DPP-4 inhibitors; 3-Amino-1-adamantanol; L-Prolinamide
Categories
Ask authors/readers for more resources
An original synthesis of vildagliptin ((S)-1-[2-(3-hydroxyadamantan-1-ylamino)acetyllpyrrolidine-2-carbonitrile), a powerful DPP-4 inhibitor, was developed. Vildagliptin was assembled from 3-amino-ladamantanol, glyoxylic acid and L-prolinamide in a 4-step reaction sequence with the isolation of only two intermediates. The procedure is competitive with existing protocols, leading to vildagliptin in 63% overall yield. (C) 2017 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
