A major review of optical coherence tomography angiography

Introduction: Recent innovations in ophthalmic imaging have led to new alternatives to conventional ocular angiography. We describe different methods of label-free angiography and their clinical utility in ophthalmic practice. Areas covered: The aim of this paper is to review the current literature on Optical Coherence Tomography Angiography (OCTA). A review of the literature was performed, including the physical principles and algorithms and OCTA features of different ocular diseases. The literature reviewed was found by searching Pubmed and Google Scholar for optical coherence tomography, OCT angiography, and label- free angiography. All results in the English language were read in full-text. Expert commentary: OCTA is an emerging, non-invasive imaging modality which can display ocular vasculature with good sensitivity and may help us detect vascular disorders of the retina and choroid. The technique's depth-resolving ability allows us to localize the origin of several disorders to the individual vascular networks of retina and choroid. In practice, OCTA can provide vascular details comparable to or better than current gold-standard, vascular imaging techniques and may be repeated and reproduced frequently without any significant complications.