4.4 Article

A highly selective fluorescent chemosensor for NADH based on calix [4]arene dimer

Journal

TETRAHEDRON
Volume 73, Issue 5, Pages 604-607

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2016.12.053

Keywords

Chemosensor; NADH; Calix[4]arene; Fluorescence

Funding

  1. Chemistry and Chemical Engineering Research Center of Iran

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A new calix[4]arene dimer (C4D) has been designed and synthesized as a fluorescent chemosensor for the recognition of NADH in aqueous media. This chemosensor showed unique selectivity toward NADH over various biomolecules, with a detection limit of 24.5 nM (16.3 mu g L-1). Moreover, the stoichiometry of the C40-NADH complex formed was found to be 1:1 and the binding constant was calculated to be 3.74 x 10(5) M-1. (C) 2016 Elsevier Ltd. All rights reserved.

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