Journal
TETRAHEDRON
Volume 73, Issue 43, Pages 6193-6198Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2017.09.013
Keywords
alpha-Chloro oxime; 2-Pyrazinone; Deep eutectic solvents; Green chemistry; Peptidomimetics
Categories
Funding
- University of Salento
- consorzio Interuniversitario Nazionale Metodologie e Processi Innovativi di Sintesi (C.I.N.M.P.I.S.)
Ask authors/readers for more resources
A novel and green synthesis of 2-pyrazinones in deep eutectic solvents (DESs) is described. Treatment of aromatic alpha-chloro oximes with aliphatic amines at 110 degrees C in choline chloride based DESs resulted in a straightforward and efficient assembly of 1,3,5-trisubstituted-2(1H)-pyrazinones. The protocol, featuring mild reaction conditions and avoiding common volatile organic solvents, affords a safe and sustainable approach to original peptidomimetic scaffolds. (C) 2017 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
