A concise enantioselective synthesis of pyrrolidine sedum alkaloids (R)-(R)-(+), (S)-(S)-(-)-pyrrolsedamine and (S)-(R)-(+)-pyrrolallosedamine by using proline catalysed α-amination reaction

A general approach for the synthesis of pyrolidine member of sedum alkaloids has been developed by employing proline catalysed sequential alpha-amination and Horner-Wadsworth-Emmons (HWE) olefination of an aldehyde as the key steps. This method can be extended for the synthesis of various bioactive natural products containing pyrolidine skeleton. (C) 2017 Published by Elsevier Ltd.