Journal
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
Volume 15, Issue 8, Pages 591-599Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/14779072.2017.1355238
Keywords
Atrial fibrillation; stroke; atrial disease; atrial cardiopathy; atrial dysfunction
Categories
Funding
- National Institutes of Health [K23 NS082367]
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Introduction: Cryptogenic stroke accounts for approximately 30% of all ischemic strokes. Recently, atrial cardiopathy diagnosed by the presence of one of its serum, imaging, or electrocardiogram biomarkers has been shown to be associated with ischemic stroke, particularly of embolic subtypes. Areas covered: This paper aims to summarize data on occult atrial fibrillation and stroke, provide an overview on mechanisms, such as inflammation and fibrosis, of stroke in atrial cardiopathy, critically review data on biomarkers of atrial cardiopathy and their association with stroke, and suggest therapeutic implications, including directions for future research. Expert commentary: Atrial cardiopathy may constitute one of the mechanisms in cryptogenic stroke, and patients with evidence of atrial cardiopathy constitute a group of patients in whom clinical trials are warranted to test anticoagulation versus antiplatelet therapy to reduce stroke recurrence risk. In addition, more studies are needed to determine the degree of overlap between these atrial cardiopathy biomarkers and which one is more useful in predicting the risk of stroke and response to anticoagulation therapy.
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