Journal
TETRAHEDRON
Volume 73, Issue 49, Pages 6906-6913Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2017.10.043
Keywords
N-Arylation; Diarylborinic acids; Chan-Lam coupling; Copper
Categories
Funding
- National Natural Science Foundation of China [21472041]
- National Key Technology R&D Program, the Ministry of Science and Technology of China [2015BAK44B00]
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N-Arylation of (benz)imidazoles and amines with diarylborinic acids as cost-effective aryl source has been efficiently effected via Cu(OAc)(2)-catalyzed Chan-Lam coupling in assistance of tetramethylethylenediamine (TMEDA) in methanol and pyridine (Py) in dichloromethane, respectively, in air at room temperature. The diarylborinic acids could be well accommodated by the Chan-Lam coupling oxidative conditions containing a proper combination of bases and solvents. The steric hindrance appeared to affect the copper-catalyzed N-arylation using the high-order arylboron reagent more significantly than the electronic factors, especially for low reactive anilines and aliphatic amines. (C) 2017 Elsevier Ltd. All rights reserved.
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