Journal
TETRAHEDRON
Volume 73, Issue 19, Pages 2786-2792Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2017.03.078
Keywords
Marine sponge; Agelas sp.; Dimeric bromopyrrole alkaloids; Sceptrin
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Funding
- National Science Foundation of China [41406139, 81225023, U1605221]
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Chemical investigation of the marine sponge Agelas sp. collected from the South China Sea resulted in the isolation of four new dimeric bromopyrrole alkaloids, including hexazosceptrin (1) with a rare cyclohexane-fused-cyclobutane skeleton, agelestes A and B (2-3), the sceptrin analogues without any aminoimidazole substitution, and (9S, 10R, 9'S, 10'R)-nakamuric acid (4), of which the absolute configuration was confirmed for the first time. The structure elucidation and absolute configuration assignments were unambiguously determined via extensive spectroscopic analyses and the comparison of experimental and calculated electronic circular dichroic spectra. Compounds 1 and 4 exhibited moderate antimicrobial activity. (C) 2017 Elsevier Ltd. All rights reserved.
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