One-pot, four-component synthesis of spiroindoloquinazoline derivatives as phospholipase inhibitors

An efficient, one-pot, two-step, four-component reaction for the synthesis of spiroindoloquinazoline derivatives in the presence of 1,4-diazabicyclo[2.2.21]octane (DABCO) is described. The syntheses are achieved by the condensation reaction of isatin derivatives, isatoic anhydride, malononitrile and carbonyl compounds under refiux in acetonitrile. Several of the resulting compounds showed moderate activity as phospholipase A2 inhibitors. (C) 2017 Elsevier Ltd. All rights reserved.