Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 47, Issue -, Pages 168-175Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2017.10.005
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Funding
- Swedish Research Council (Medicine and Health) [2015-03558]
- European Union (FP7/Marie Curie Integration Grant EPIOPC)
- European Union (Horizon 2020 European Research Council Consolidator Grant EPIScOPE)
- Swedish Brain Foundation
- Ming Wai Lau Centre for Reparative Medicine at Karolinska Institutet
- Swedish Cancer Society (Cancerfonden)
- Petrus och Augusta Hedlunds Foundation
- Karolinska Institutet
- Swedish Research Council [2015-03558] Funding Source: Swedish Research Council
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Oligodendrocytes (OLs) are glial cells in the central nervous system (CNS), which produce myelin, a lipid-rich membrane that insulates neuronal axons. The main function ascribed to OLs is to regulate the speed of electric pulse transmission, and as such OLs have been widely considered as a single and discrete population. Nevertheless, OLs and their precursor cells (OPCs) throughout the CNS have different morphologies and regional functional differences have been observed. Moreover, OLs have recently been involved in other functional processes such as metabolic coupling with axons. In this review, we focus on recent advances in single-cell transcriptomics suggesting that OLs are more heterogeneous than previously thought, with defined subpopulations and cell states that are associated with different stages of lineage progression and might also represent distinct functional states.
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