Redemitting BODIPY boronic acid fluorescent sensors for detection of lactate

Two redemitting BODIPY boronic acid pinacolate derivatives, sensors 1 and 2 were shown to act as excellent and highly selective lactate detectors at physiological pH (7.4), where the formed sensor-lactate complexes exhibited a significant emission and absorption increase. Since hyperlactataemia ([L-lac] > 6.5 mM) is a common complication in intensive care units, there is need for easy, on-line monitoring of lactate levels in patients. Semi-invasive monitoring via a lactate electrode or optic fiber would be attractive. This may beneficially replace existing lactate detection methods requiring a high degree of instrumentation. Sensors 1 and 2 can detect lactate without interference from biological important monosaccharides, such as D-glucose, D-fructose and D-mannose. (C) 2017 Elsevier Ltd. All rights reserved.