Journal
MOLECULAR & CELLULAR ONCOLOGY
Volume 4, Issue 5, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2017.1353854
Keywords
Autophagy; metabolic reprogramming; hypoxia; BNiP3L
Categories
Funding
- Spain's Ministerio de Economia y Competitividad [BFU2015-65623, BFU2015-71869-REDT]
- COST Action Transautophagy [CA15138]
- ITN [MSCA-ITN-ETN 765912]
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Mitophagy is the process by which cells eliminate damaged or superfluous mitochondria by degrading them within lysosomes. We show that during development, selective removal of mitochondria by autophagy induces a metabolic shift toward glycolysis that is essential for differentiation of several cell types. These findings suggest potential applications of cell-fate manipulation strategies targeting mitophagy.
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