Journal
CHEMICAL RESEARCH IN TOXICOLOGY
Volume 30, Issue 12, Pages 2097-2099Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrestox.7b00291
Keywords
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Funding
- Cystic Fibrosis Trust [PJ533]
- Centre for Drug Safety Science - Medical Research Council [G0700654]
- MRC [MR/L006758/1] Funding Source: UKRI
- Medical Research Council [MR/L006758/1] Funding Source: researchfish
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The risk of developing hypersensitivity to alternative antibiotics is,a concern for penicillin hypersensitive patients and healthcare providers. Herein we use piperacillin hypersensitivity as a model to explore the reactivity of drug-specific IgG against alternative beta-lactain protein adducts. Mass spectrometry was used to show the drugs (amoxicillin, flucloxacillin, benzyl penicillin, aztreonam, and piperacillin) bind to similar lysine residues on the protein carrier bovine serum albumin. However, the hapten-specific IgG antibodies found in piperacillin hypersensitive patient plasma did not bind to other beta-lactam protein conjugates. These data outline the fine specificity of piperacillin-specific IgG antibodies that circulate in patients with hypersensitivity.
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