Journal
ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY
Volume 13, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s13223-017-0223-8
Keywords
Follow-up; Food allergy; Maintenance dosing; Omalizumab; Oral immunotherapy
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Funding
- NIAID [R21AI095838, U19AI104209]
- Myra Reinhard family Foundation
- Sean N. Parker Center for Allergy and Asthma Research at Stanford University
- Food Allergy Research and Education Center of Excellence
- Trip Advisor Inc.
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Background: A number of clinical studies focused on treating a single food allergy through oral immunotherapy (OIT) with adjunctive omalizumab treatment have been published. We previously demonstrated safety and tolerability of a rapid OIT protocol using omalizumab in a phase 1 study to achieve desensitization to multiple (up to 5) food allergens in parallel, rapidly (7-36 weeks; median = 18 weeks). In the current long-term, observational study, we followed 34 food allergic participants for over 5 years, who had originally undergone the phase 1 rapid OIT protocol. Methods: After reaching the maintenance dose of 2 g protein for each of their respective food allergens as a part of the phase 1 study, the long-term maintenance dose was reduced for some participants based on a pragmatic team-based decision. Participants were followed up to 62 months through standard oral food challenges (OFCs), skin prick tests, and blood tests. Results: Each participant passed the 2 g OFC to each of their offending food allergens (up to 5 food allergens in total) at the end of the long-term follow-up (LTFU) study. Conclusion: Our data demonstrate the feasibility of long-term maintenance dosing of a food allergen without compromising the desensitized status conferred through rapid-OIT.
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