Journal
DISEASE MARKERS
Volume 2017, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2017/8458492
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Funding
- Beijing NOVA Program [Z171100001117027]
- Key Projects in the National Science and Technology Pillar Program during the 12th Five-Year Plan Period [2011BAI11B05]
- Beijing Lab for Cardiovascular Precision Medicine [PXM2017_014226_000037]
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Objective. The aim of the present study was to investigate the predictive value of neutrophil count for no-reflow in patients with ST-segment elevation myocardial infarction (STEMI) who underwent successful primary percutaneous intervention (PCI). Methods. We conducted a retrospective study of 361 patients diagnosed with acute STEMI between 2011 and 2015. All patients underwent successful PCI within 12 h from the onset of symptoms. Angiographic no-reflow was diagnosed based on a post-PCI thrombolysis in myocardial infarction flow grade <= 2 without mechanical obstruction. According to a neutrophil count cut-off determined by receiver operating characteristic curve analysis, patients were divided into two groups: group A (neutrophil count < 9.14 x 10(9)/L) and group B (neutrophil count >= 9.14 x 10(9)/L). Results. Compared to patients in the normal reflow group, patients with no-reflow had higher neutrophil counts (P < 0.05). The incidence rate of no-reflow in group A (18, 9.3%) was significantly lower than that in group B (38). Multivariate logistic regression analysis revealed that a neutrophil count >= 9.14 x 10(9)/L was independently predictive for no-reflow (odds ratio = 4.474, 95% confidence interval: 1.610-12.433, P = 0 004) after adjusting for potential confounders. Conclusions. A circulating neutrophil count >= 9.14 x 10(9)/L is independently associated with no-reflow in patients with acute STEMI following primary PCI.
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