Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 159, Issue -, Pages 605-612Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2017.08.016
Keywords
Janus glycodendrimer; Lectin inhibitors; Photoswitchable amphiphiles
Funding
- Australian Research Council [DE130101673]
- Helmholtz-Association [VH-NG-934]
- Australian Centre for Neutron Scattering
- Australian Nuclear Science and Technology Organisation
- NSF [DMR-0520547]
- Australian Research Council [DE130101673] Funding Source: Australian Research Council
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The first example of the self-assembly and lectin binding properties of photoswitchable glycodendrimer micelles is reported. Light-addressable micelles were assembled from a library of 12 amphiphilic Janus glycodendrimers composed of variable carbohydrate head groups and hydrophobic tail groups linked to an azobenzene core. Spontaneous association in water gave cylindrical micelles with uniform size distribution as determined by dynamic light scattering (DLS) and small angle neutron scattering (SANS). Trans-cis photoisomerization of the azobenzene dendrimer core was used to probe the self-assembly behaviour and lectin binding properties of cylindrical micelles, revealing moderate-to-potent inhibition of lectins LecA and LecB from Pseudomonas aeruginosa. Crown Copyright (C) 2017 Published by Elsevier B.V. All rights reserved.
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