Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 159, Issue -, Pages 259-267Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2017.07.055
Keywords
Cyclo-oligosaccharides; Cyclosophoraose; Palmitoyl chloride; Phase-change; Nanoemulsions; Ultrasound
Funding
- Portuguese Foundation for Science and Technology (FCT) [UID/BIO/04469/2013]
- COMPETE [POCI-01-0145-FEDER-006684]
- BioTecNorte operation - European Regional Development Fund under the scope of Norte - Programa Operacional Regional do Norte [NORTE-01-0145-FEDER-000004]
- European Union Horizon research and innovation programme [NMP-06-2015-683356 FOLSMART]
- FCT- Fundagdo para a Ciencia e a Tecnologia [SFRH/BD/121673/2016]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/121673/2016] Funding Source: FCT
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New encapsulation nanodevices were synthesized by emulsification of cyclo-oligosaccharides fully substituted by hydrophobic palmitic chains. These highly hydrophobic compounds, acquire oily-like behaviour at moderate temperatures (similar to 50 degrees C) and when submitted to ultrasound (US) can undergo emulsification. The improved emulsifying properties of modified cyclo-oligosaccharides are suitable to produce small and narrow sized nanoemulsions with ability to encapsulate amphiphilic molecules. Both encapsulation and delivery of a therapeutic drug, methotrexate (MTX), with amphiphilic character was assessed. The physicochemical properties of the cyclo-oligosaccharide nanoemulsions containing MTX were investigated by nuclear magnetic resonance (NMR), scanning transmission electron microscopy (STEM) and dynamic light scattering (DLS). The results revealed that the modified cyclo-oligosaccharides are potential platforms for the encapsulation of bio compounds for cosmetic and pharmaceutical purposes. (C) 2017 Elsevier B.V. All rights reserved.
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