Journal
TALANTA
Volume 162, Issue -, Pages 225-231Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2016.10.026
Keywords
Hydrazine; Fluorescent probe; Nucleophilic aromatic substitution (NAS) reaction; Bioimaging
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Funding
- National Natural Science Foundation of China [21575045, 21405041, 21190041, 21221003]
- National Key Basic Research Program [2011CB911000]
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A turn-on fluorescent probe (Naphsulf-O) for hydrazine was developed by protecting the hydroxy group of the fluorophore 6-acetyl-2-hydroxynaphthalene via O-4-nitrobenzenesulfonylation, where 4-nitrobenzene was used as a fluorescence quenching moiety as well as an electrophile. Upon nucleophilic aromatic substitution (NAS) reaction of hydrazine toward the probe, the protecting group was removed and fluorophore was released. The probe exhibits a large Stokes shift, excellent selectivity and high sensitivity for hydrazine detection in aqueous solution with a detection limit of 0.716 ppb (22 nM), which is of great importance in both environmental and biological system. Furthermore, it was successfully applied to imaging of hydrazine in living cells.
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