Journal
TALANTA
Volume 170, Issue -, Pages 89-96Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2017.03.108
Keywords
Fluorescein derivatives; Fluorescence-enhancement; Water-soluble; Hg2+ detection; Living cell imaging
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Funding
- National Natural Science Foundation of China [21671037, 21471030, 21277103, 81560407, 21271040]
- Department of Science and Technology of Guizhou Province [2015SY3046]
- Joint Foundation of Guizhou Province [2015LH7505]
- Science and Technology Foundation of Guizhou Province [2013J2312]
- Doctoral Scientific Research Foundation of Affiliated Hospital of Zunyi Medical College [2014-7]
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To improve the water-solubility of heavy-metal sensing materials, a modified fluorescein-based derivative, acryloyl fluorescein hydrazine (ACFH), was designed and developed by incorporating a non-hydrogen-bonding group into the conjugated molecule for weakening intermolecular hydrogen-bonding interactions. In neutral water environments, ACFH presented a fluorescence-enhancement performance at lambda(max)=512 rim in the presence of Hg2+, which could be visualized by naked-eyes. Under the optimized conditions, the linear range of Hg2+ detection was 1.0-100x10(-9) mol L-1 with a correlation coefficient of 0.9992 and a detection limit of 0.86x10(-9) mol L-1. The recognition mechanism was confirmed to be a stable and irreversible 1:1 five-member ring complex between ACFH and Hg2+ with a coordination constant of 3.36x10(9). ACFH would possess a potential application in detecting Hg2+ for biological assay with low cytotoxicity.
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