Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 47, Issue -, Pages 105-112Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2017.07.005
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Funding
- U.S. National Science Foundation [IOS-1025636, IOS-1546617]
- Plant Biotechnology for Health and Sustainability Graduate Training Program - U.S. National Institutes of Health training grant [T32-GM110523]
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [1546617] Funding Source: National Science Foundation
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Specialized metabolic enzymes and metabolite diversity evolve through a variety of mechanisms including promiscuity, changes in substrate specificity, modifications of gene expression and gene duplication. For example, gene duplication and substrate binding site changes led to the evolution of the glucosinolate biosynthetic enzyme, AtIPMDH1, from a Leu biosynthetic enzyme. BAND acyltransferases illustrate how enzymatic promiscuity leads to metabolite diversity. The examples 4-coumarate:CoA ligase and aromatic acid methyltransferases illustrate how promiscuity can potentiate the evolution of these specialized metabolic enzymes.
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