4.3 Article

Efficient synthesis of acridinediones in aqueous media

Journal

SYNTHETIC COMMUNICATIONS
Volume 47, Issue 10, Pages 1013-1019

Publisher

TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2017.1304556

Keywords

Acridinedione; ammonium acetate; benzaldehyde; dimedone; enaminone

Funding

  1. Department of Pharmaceuticals, Ministry of Chemical and Fertilizers, Govt. of India

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An efficient synthesis of acridinediones in two steps have been achieved using water as a reaction media without chromatographic purification. First step involves the reaction of dimedone with ammonium acetate to yield enaminone in water which on further reaction with various aldehydes yields acridinedione in aqueous media. The reaction merits the use of water as solvent, no additive catalyst and provides high yield of products with good purity.

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