Journal
SYNTHETIC COMMUNICATIONS
Volume 47, Issue 20, Pages 1884-1904Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2017.1355466
Keywords
Boron nitride; Claisen-Schmidt reaction; HSA protein; molecular docking
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Funding
- National Research Foundation (NRF)
- Durban University of Technology (DUT)
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An efficient and environmentally benign one-pot multicomponent synthesis of E-chalcones was developed using a mild and reusable new boron nitride-sulphonic acid catalyst. The catalyst was prepared by activating the boron nitride surface with nitric acid, followed by a simple reaction with 3-mercaptopropyl trimethoxysilane. The catalyst was characterized and morphological properties were studied by Fourier transform infrared, X-ray diffraction, transmission electron spectroscopy, scanning electron microscopy, Brunauer-Emmett-Teller theory, and Raman spectroscopy techniques. The solid acid catalyst was recycled five times in a Claisen-Schmidt reaction to synthesize new chalcone derivatives, and X-ray crystallography was used to elucidate the structure of (E)-1-(anthracen-9-yl)-3-(2-(4-methylpiperazin-1-yl)quinolin-3-yl)prop-2-en-1-one. A fluorescence quench titration method was used to assess its binding ability with human serum albumin (HSA), while molecular docking was also performed to get a more detailed insight into their interaction at the binding site of HSA. [GRAPHICS] .
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