Journal
SYNTHESIS-STUTTGART
Volume 49, Issue 24, Pages 5351-5356Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0036-1588553
Keywords
Streptomyces; antifungal agents; tripeptides; natural products; amino acids; total synthesis
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A short and efficient synthesis of resormycin, a metabolite of Streptomyces platensis MJ953-SF5 with herbicidal and antifungal activity, is described. The key step in our synthetic approach is a late-stage stereospecific dehydration of a beta-hydroxy amino acid to install the Z-olefin. Because of the modular nature of the synthesis, access to analogues for biological evaluation is readily available.
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