Journal
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
Volume 31, Issue 1, Pages 42-52Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.berh.2017.07.005
Keywords
Arthralgia; Pre-clinical rheumatoid arthritis; Rheumatoid factors; Anti-citrullinated protein antibodies; Epitope spreading; Glycosylation; Autoantibody interactions
Categories
Funding
- ZonMw, the Netherlands' Organisation for Health Research and Development [436001001]
Ask authors/readers for more resources
Autoantibodies such as rheumatoid factors (RFs), anti-citrullinated protein antibodies (ACPAs), and other anti-modified protein anti-bodies are important risk factors for the development of rheumatoid arthritis (RA) and probably play an important role in its pathogenesis. In the phase before clinical arthritis becomes apparent, different autoantibody responses can evolve because of increases in their level, isotype switching, affinity maturation, epitope spreading, and a changing glycosylation profile. This evolution may be crucial for the pathogenic properties of the autoantibody responses, and interfering with this process in individuals at risk may become a route to prevent RA. Recent data suggest that interactions between RFs and ACPAs further amplify their inflammatory potential. (C) 2017 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available