Journal
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Volume 97, Issue 3, Pages 944-948Publisher
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.16-1003
Keywords
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Funding
- Takeda Pharmaceuticals [IISR-2014-100647]
- NIH/NCATS Colorado CTSI Grant [UL1 TR001082]
- Children's Hospital of Colorado Research Scholar Award
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We examined burden and factors associated with norovirus (NoV) acute gastroenteritis (AGE) among children in rural Guatemala. Children age 6 weeks to 17 years were enrolled into three AGE surveillance groups, using two-stage cluster sampling: a prospective participatory syndromic surveillance (PSS) cohort and two cross-sectional rapid active sampling (RAS) surveys, conducted from April 2015 to February 2016. Epidemiologic and NoV testing data were used to identify factors associated with NoV infection, AGE, and NoV+AGE. The three cross-sectional surveys (PSS enrollment visit, RAS Survey 1, and RAS Survey 2) enrolled 1,239 children, who reported 134 (11%) AGE cases, with 20% of AGE and 11% of non-AGE samples positive for NoV. Adjusted analyses identified several modifiable factors associated with AGE and NoV infection. The cross-sectional RAS surveys were practical and cost-effective in identifying population-level risk factors for AGE and NoV, supporting their use as a tool to direct limited public health resources toward high-risk populations.
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