Journal
CELL CYCLE
Volume 16, Issue 21, Pages 2037-2045Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15384101.2017.1376149
Keywords
PEX5; Ubiquitination; Peroxisome; Biogenesis; Turnover; Homeostasis
Categories
Funding
- NIH [5RO1 DK41737]
Ask authors/readers for more resources
Peroxisomes are essential and dynamic organelles that allow cells to rapidly adapt and cope with changing environments and/or physiological conditions by modulation of both peroxisome biogenesis and turnover. Peroxisome biogenesis involves the assembly of peroxisome membranes and the import of peroxisomal matrix proteins. The latter depends on the receptor, PEX5, which recognizes peroxisomal matrix proteins in the cytosol directly or indirectly, and transports them to the peroxisomal lumen. In this review, we discuss the role of PEX5 ubiquitination in both peroxisome biogenesis and turnover, specifically in PEX5 receptor recycling, stability and abundance, as well as its role in pexophagy (autophagic degradation of peroxisomes).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available