Journal
EPILEPSY RESEARCH
Volume 113, Issue -, Pages 98-103Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.eplepsyres.2015.03.018
Keywords
VNS; EEG; Functional connectivity; Synchrony; Epilepsy
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EEG desynchronization has been proposed to be an important mechanism for antiepileptic effect of vagus nerve stimulation (VNS) but has never been clearly documented in human. The aim of this study was to evaluate impact of VNS on the synchronicity of interictal EEG rhythms. We estimated synchronization between scalp EEG signals using phase lag index (PLI) in 19 patients with chronic VNS therapy. We estimated changes in synchronization between ON and OFF phases and between responder (R) and non-responder (NR) patients. We found that R have a lower global level of synchronization (EEG broadband) than NR (p< 0.0001) In addition, ON periods were characterized by lower values in comparison with OFF periods (p< 0.001). R had significantly lower global synchronization levels in delta and alpha frequency bands (p<0.0001). Patients responding to VNS have thus a lower level of broadband EEG synchronization than non-responders. Estimating changes of synchronization level is thus a promising tool for predicting response to VNS. (C) 2015 Elsevier B.V. All rights reserved.
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