Journal
EPILEPSY & BEHAVIOR
Volume 49, Issue -, Pages 13-16Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yebeh.2015.04.047
Keywords
Status epilepticus; Blood-brain barrier; Leakage; Inflammation; Angiogenesis; Immune response; Epilepsy
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Funding
- European Union Seventh Framework Programme [602102 (EPITARGET)]
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Over the last 15 years, attention has been focused on dysfunction of the cerebral vasculature and inflammation as important players in epileptogenic processes, with a specific emphasis on failure of the blood-brain barrier (BBB; Fig. 1) (Seiffert et al., 2004; Marchi et al., 2007; Oby and Janigro, 2006; van Vliet et al., 2014; Vezzani et al., 2011) [3-7]. Here, we discuss how the BBB is disrupted as a consequence of SE and how this BBB breakdown may be involved in epileptogenesis. (C) 2015 Elsevier Inc. All rights reserved.
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