Journal
MOLBANK
Volume -, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/M964
Keywords
(S)-2-piperazinecarboxylic acid; tricyclic benzodiazepines; isatoic anhydride; cytotoxicity
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Funding
- National Science Center [DEC-2011/01/B/NZ4/03566]
- European Regional Development Fund and Innovative Economy
- National Cohesion Strategy of Poland
- European Union from the European Regional Development Fund, under the Operational Program Innovative Economy
- National Science Centre, Poland, MAESTRO [DEC-2012/04/A/ST5/00609]
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(S)-2-(4-Chlorobenzoyl)-1,2,3,4-tetrahydrobenzo[e]pyrazino[1,2-a][1,4] diazepine-6,12(11H, 12aH)-dione was obtained in a three-step, one-pot synthesis, starting from optically pure (S)-2-piperazine carboxylic acid dihydrochloride. Selective acylation of the beta-nitrogen atom followed by condensation with isatoic anhydride and cyclization with HATU/DIPEA to a seven-member benzodiazepine ring, led to the tricyclic benzodiazepine derivative. Crystallographic studies and initial biological screening were performed for the title compound.
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