Journal
DRUG DELIVERY
Volume 24, Issue 2, Pages 94-107Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10717544.2017.1399300
Keywords
Mesoporous carbon nanomaterials; biocompatibility; drug delivery systems; photothermal therapy; biomedical applications
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Funding
- National Basic Research Program of China (973 Program) [2015CB932100]
- National Natural Science Foundation of China [81273449, 81603058]
- Liaoning Provincial Key Laboratory of Drug Preparation Design AMP
- Evaluation of Liaoning Provincial Education Department [LZ2015068]
- Career Development Program for Young Teachers in Shenyang Pharmaceutical University [ZQN2016025]
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Recent development of nano-technology provides highly efficient and versatile treatment methods to achieve better therapeutic efficacy and lower side effects of malignant cancer. The exploration of drug delivery systems (DDSs) based on nano-material shows great promise in translating nano-technology to clinical use to benefit patients. As an emerging inorganic nanomaterial, mesoporous carbon nanomaterials (MCNs) possess both the mesoporous structure and the carbonaceous composition, endowing them with superior nature compared with mesoporous silica nanomaterials and other carbon-based materials, such as carbon nanotube, graphene and fullerene. In this review, we highlighted the cutting-edge progress of carbon nanomaterials as drug delivery systems (DDSs), including immediate/sustained drug delivery systems and controlled/targeted drug delivery systems. In addition, several representative biomedical applications of mesoporous carbon such as (1) photo-chemo synergistic therapy; (2) delivery of therapeutic biomolecule and (3) in vivo bioimaging are discussed and integrated. Finally, potential challenges and outlook for future development of mesoporous carbon in biomedical fields have been discussed in detail.
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