Journal
CLINICAL PLASMA MEDICINE
Volume 7-8, Issue -, Pages 52-57Publisher
ELSEVIER
DOI: 10.1016/j.cpme.2017.09.002
Keywords
Cold atmospheric plasma; Head and neck cancer; Hyperspectral imaging; Maxillofacial surgery; Microcirculation; Wound healing
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Beside a proven antimicrobial and inflammatory-modulating spectrum of plasma therapy, recent studies point to impressive molecular and cellular effects against tumor cells. However, underlying mechanisms of anticancer effects and improved wound healing, in particular plasma associated influence on microcirculation, have not been sufficiently clarified yet. To date, there is no convincing method for monitoring therapy with cold atmospheric plasma (CAP) in vivo. TIVITA (TM) Tissue System is an innovative hybrid technology that combines imaging and spectroscopy for assessment and documentation of tissue. By collecting spectral information, HSI generates a three-dimensional (3D) data cube that enables calculation of different microcirculation parameters. In this research two patients were treated with CAP in context of head and neck tumor therapy. HSI was able to demonstrate CAP associated effects on microcirculation showing a relevant increase of superficial and deeper cutaneous oxygen saturation, hemoglobin concentration and distribution. This effect may contribute to healing support by CAP in wounds as well as tumor disease. Still in scientific development, HSI appears to be suitable for analyzing and monitoring CAP effects in clinical setting. With regard to the limited amount of data, these findings must be verified in a larger study population.
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