Journal
2017 IEEE 12TH INTERNATIONAL CONFERENCE ON NANO/MICRO ENGINEERED AND MOLECULAR SYSTEMS (NEMS)
Volume -, Issue -, Pages 313-317Publisher
IEEE
Keywords
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Funding
- National Institutes of Health [R01AI113257]
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This paper presents a finger-powered microfluidic electrochemical assay for rapid measurements of protein biomarkers. This device employs a valveless, piston-based pumping mechanism which utilizes a human finger for the actuation force. Liquids are driven inside microchannels by pressing on pistons which generate pressure-driven flows. Reagents are preloaded in microwells allowing for the entire testing process to be completed on-chip. For proof-of-concept, this device was used to detect Plasmodium falciparum histidine-rich protein-2 (PfHRP2) in human plasma samples using a mobile phone biosensing platform. Using this device, PfHRP2 was detected from 0.1 to 20 mu g/mL with high specificity and each measurement could be completed in <= 6 min. Based on its simplicity, portability and good analytical performance, this platform is promising for point-of-care testing, particularly in remote and resource-limited regions.
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