4.7 Article

Electroacupuncture Promotes Central Nervous System-Dependent Release of Mesenchymal Stem Cells

Journal

STEM CELLS
Volume 35, Issue 5, Pages 1303-1315

Publisher

WILEY
DOI: 10.1002/stem.2613

Keywords

Mesenchymal stem cells; Adult stem cells; Nervous system; Neurones

Funding

  1. National Cancer Institute [P30. CA082709]
  2. NIH [R01EY012601-15, R01HL11070-03, R01DK090730-04, R01EY007739-23, U54 DK106846-01, R01 HL109602, PR151924, DK100905, R01DK100905, 101BX002209]
  3. St. Vincent Foundation
  4. Cryptic Masons' Medical Research Foundation
  5. CDMRP [893837, PR151924] Funding Source: Federal RePORTER

Ask authors/readers for more resources

Electroacupuncture (EA) performed in rats and humans using limb acupuncture sites, LI-4 and LI-11, and GV-14 and GV-20 (humans) and Bai-hui (rats) increased functional connectivity between the anterior hypothalamus and the amygdala and mobilized mesenchymal stem cells (MSCs) into the systemic circulation. In human subjects, the source of the MSC was found to be primarily adipose tissue, whereas in rodents the tissue sources were considered more heterogeneous. Pharmacological disinhibition of rat hypothalamus enhanced sympathetic nervous system (SNS) activation and similarly resulted in a release of MSC into the circulation. EA-mediated SNS activation was further supported by browning of white adipose tissue in rats. EA treatment of rats undergoing partial rupture of the Achilles tendon resulted in reduced mechanical hyperalgesia, increased serum interleukin-10 levels and tendon remodeling, effects blocked in propranolol-treated rodents. To distinguish the afferent role of the peripheral nervous system, phosphoinositide-interacting regulator of transient receptor potential channels (Pirt)-GCaMP3 (genetically encoded calcium sensor) mice were treated with EA acupuncture points, ST-36 and LIV-3, and GV-14 and Bai-hui and resulted in a rapid activation of primary sensory neurons. EA activated sensory ganglia and SNS centers to mediate the release of MSC that can enhance tissue repair, increase anti-inflammatory cytokine production and provide pronounced analgesic relief. Stem Cells2017;35:1303-1315

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available