Journal
STEM CELL REVIEWS AND REPORTS
Volume 13, Issue 5, Pages 567-574Publisher
SPRINGER
DOI: 10.1007/s12015-017-9747-z
Keywords
Lung; Hematopoietic stem cells; Origin; Niche
Funding
- Pro-reitoria de Pesquisa/Universidade Federal de Minas Gerais (PRPq/UFMG) [Edital 05/2016]
- National Institute of Health [1R01CA179072-01A1]
- American Cancer Society Mentored Research Scholar grant [124443-MRSG-13-121-01-CDD]
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Platelets are released from megakaryocytes. The bone marrow has been proposed to be the major site where this process occurs. LefranCais et al. (2017) using state-of-the-art techniques including two-photon microscopy, in vivo lineage-tracing technologies, and sophisticated lung transplants reveal that the lung is also a primary site for platelet biogenesis. Strikingly, lung megakaryocytes can completely reconstitute platelet counts in the blood in mice with thrombocytopenia. This study also shows that hematopoietic progenitors, with capacity to repopulate the bone marrow after irradiation, are present in the lungs. This work brings a novel unexpected role for the lung as a niche for hematopoiesis. The emerging knowledge from this research may be important for the treatment of several disorders.
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