Journal
TRENDS IN CANCER
Volume 3, Issue 6, Pages 423-441Publisher
CELL PRESS
DOI: 10.1016/j.trecan.2017.04.007
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Funding
- Spanish Ministry of Economy and Competitiveness [Fondo de Investigaciones Sanitarias (FIS)] [PI15/00558]
- Fondos Feder
- research contract 'Sara Borrell' (ISCIII-MINECO-Spain/FEDER-EU) [CD14/00005]
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A wealth of evidence supports an association between regular physical activity (PA) and decreased risk for cancer and cancer mortality. This is clearly an important issue given the growing worldwide incidence of both cancer and physical inactivity. Of further importance is unraveling the biological mechanisms that explain the potential preventive effects of PA against the development of cancer, as this might improve our understanding of cancer biology and assist researchers exploring novel treatment strategies. Here we review mechanistic studies that help explain the anticancer effects of exercise based on how exercise impacts hallmark features of cancer. We also discuss the emerging role of myokines, methodological caveats in the field, and potential questions that remain to be addressed in future research.
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