Journal
EPILEPSIA
Volume 56, Issue 10, Pages 1492-1504Publisher
WILEY
DOI: 10.1111/epi.13108
Keywords
Antiepileptic drugs; Cognition; Epileptiform discharges; Memory; Sleep
Categories
Funding
- Fundacion Alfonso Martin Escudero
- HHV6 Foundation
- Patient-Centered Outcomes Research Institute
- Payer Provider Quality Initiative
- American Epilepsy Society
- Epilepsy Foundation of America
- Epilepsy Therapy Project
- Pediatric Epilepsy Research Foundation
- Citizens United for Research in Epilepsy (CURE)
- Danny Did Foundation
- Eisai Inc
- Lundbeck
- Upsher Smith
- U.S. Department of Defense
- NINDS [NS-78333]
- UCB
- Heffer Family Foundation
- Barry Segal Family Foundation
- Abbe Goldstein/Joshua Lurie family
- Laurie Marsh/Dan Levitz family
- National Institutes of Health (NIH) [NS-78333, NS43209, NS20253, NS45911]
Ask authors/readers for more resources
To evaluate the impact of epileptiform discharges (EDs) that do not occur within seizure patterns - such as spikes, sharp waves or spike waves - on cognitive function and to discuss the circumstances under which treatment of EDs might be considered. Methods used in this article is Review of the literature. EDs may disrupt short-term cognition in humans. Frequent EDs for a prolonged period can potentially impair long-term cognitive function in humans. However, there is conflicting evidence on the impact of EDs on long-term cognitive outcome because this relationship may be confounded by multiple factors such as underlying etiology, seizures, and medication effects. Limitations of existing studies include the lack of standardized ED quantification methods and of widely accepted automated spike quantification methods. Although there is no solid evidence for or against treatment of EDs, a non-evidence-based practical approach is suggested. EDs in otherwise asymptomatic individuals should not be treated because the risks of treatment probably outweigh its dubious benefits. A treatment trial for EDs may be considered when there is cognitive dysfunction or regression or neurologic symptoms that are unexplained by the underlying etiology, comorbid conditions, or seizure severity. In patients with cognitive or neurologic dysfunction with epilepsy or EDs, treatment may be warranted to control the underlying epileptic syndrome. EDs may cause cognitive or neurologic dysfunction in humans in the short term. There is conflicting evidence on the impact of EDs on long-term cognitive outcome. There is no evidence for or against treatment of asymptomatic ED.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available