Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 173, Issue -, Pages 207-212Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2016.09.023
Keywords
Glucose; Colorimetric method; Gold nanoparticles; Silver nanoparticles
Categories
Funding
- National Natural Science Foundation of China [21475092]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
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We have coupled gold nanoparticles (AuNPs) with silver nanoparticles (AgNPs) to assemble a plasmonic sensing platform for colorimetric detection of glucose. In this system, small AuNPs (similar to 4 nm) can act as glucose oxidase (GOD) mimic enzyme to catalytically oxidize glucose in the presence of oxygen, producing hydrogen peroxide, which dissolves AgNPs to lead the color changes. Glucose can be detected not only by naked eyes (from yellow to red) but also by spectrophotometer in the concentration range of 5-70 mu M, with detection limit of 3 mu M. More importantly, we found that L-cysteine added in the system can markedly improve the selectivity for the detection of glucose. The proposed method was used to application for the detection of glucose in human serum with satisfactory results. This system is simple and low cost without using any enzymes and organic chromogenic agents. (C) 2016 Elsevier B.V. All rights reserved.
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